Publications by authors named "C Clare Strange"
Background: Despite guideline recommendations, most patients with COPD do not undergo alpha-1 antitrypsin deficiency (AATD) testing and approximately 90% of people with AATD in the US remain undiagnosed. This study sought to develop a predictive model using real-world data to improve detection of AATD-positive patients in the general COPD population.
Methods: A predictive model using XGBoost was developed using the EVERSANA database, including longitudinal, patient-level medical claims, prescription claims, AATD-specific testing data, and electronic health records (EHR).
Article Synopsis
- * A study compared lung tissue samples from patients with systemic sclerosis-associated PAH, idiopathic PAH, and healthy controls to identify differences in lung pathology and treatment response.
- * Findings showed that idiopathic PAH has plexiform lesions present, while systemic sclerosis-associated PAH has significantly worse interstitial fibrosis and cellularity, but similar levels of smooth muscle hypertrophy.
Article Synopsis
- Chronic pancreatitis is a progressive condition that damages both the hormone-producing and digestive functions of the pancreas; previous studies hinted at the potential of using mesenchymal stem cells (MSCs) for treatment.
- The researchers created immortalized versions of MSCs (iMSCs) and those overexpressing alpha-1 antitrypsin (iAAT-MSCs) to enhance their viability for treatment and tested these cells against TNBS-induced cell death in laboratory conditions.
- Both iMSCs and iAAT-MSCs demonstrated protective effects against cell death by reducing stress in cells, improving energy production, and minimizing oxidative damage, while also uncovering the role of ferroptosis as a new mechanism of cell death
Background: The Short Form 36-Item Health Survey (SF-36) is a health-related quality of life (HRQoL) measure validated in people with chronic obstructive pulmonary disease (COPD). While physical health is often more impaired than mental health in people with COPD, research on alpha-1 antitrypsin deficiency (AATD)-associated COPD is limited. This longitudinal study examines changes in physical and mental health in individuals with AATD and associated factors.
View Article and Find Full Text PDFBackground: Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease associated with respiratory muscle weakness and activity-limiting symptoms such as dyspnea. Respiratory muscle strength training (RMST) is an empirically validated therapy to increase respiratory muscle strength. The theoretically-informed, technology-enhanced RESPiratory FITness (RESP-FIT) intervention for COPD is a 6-week combined inspiratory and expiratory muscle strength training program with symptom measurement in real time via ecological momentary assessment (EMA).
View Article and Find Full Text PDF