Publications by authors named "C Claes"
Background: The skin prick test (SPT) is the gold standard for identifying allergic sensitization in individuals suspected of inhalant allergy. A novel device, SPAT or Skin Prick Automated Test, that enables more standardized allergy testing has been developed. Previous research has shown reduced intra-subject variability of histamine wheals by SPAT.
View Article and Find Full Text PDFIntroduction: Adults with intellectual disabilities have an increased vulnerability to mental health problems and challenging behaviour. In addition to psychotherapeutic or psychoeducational methods, off-label pharmacotherapy, is a commonly used treatment modality.
Objective: The aim of this study was to establish evidence-based guideline recommendations for the responsible prescription of off-label psychotropic drugs, in relation to Quality of Life (QoL).
Despite numerous prior attempts to improve knock-in (KI) efficiency, the introduction of precise base pair substitutions by the CRISPR-Cas9 technique in zebrafish remains challenging. In our efforts to generate KI zebrafish models of human CACNA1C mutations, we have tested the effect of several CRISPR determinants on KI efficiency across two sites in a single gene and developed a novel method for early selection to ameliorate KI efficiency. We identified optimal KI conditions for Cas9 protein and non-target asymmetric PAM-distal single stranded deoxynucleotide repair templates at both cacna1c sites.
View Article and Find Full Text PDFArticle Synopsis
- - The study synthesized and characterized nine different coinage metal π complexes of diborenes, using techniques like NMR spectroscopy and X-ray crystallography, to explore their structural and electronic properties.
- - Optical properties were analyzed through various spectroscopy methods, revealing how structural modifications significantly impact visible light absorption, photostability, and quantum yields of these compounds.
- - The research suggests that while these complexes showcase fluorescence with nanosecond lifetimes, the potential for long-lived triplet excited states exists by adjusting ligand substitution and metal centers, indicating future applications in photonics.
Article Synopsis
- - Microglia play a critical role in Alzheimer's disease, but their specific influence on disease progression and lifespan is not well understood.
- - Researchers created a mouse model lacking microglia, leading to an increase in cerebral amyloid angiopathy, brain calcification, hemorrhages, and premature death; injecting healthy microglia reversed these effects.
- - Analysis of human Alzheimer's tissue revealed that microglia can engulf calcium crystals, a process hindered by the loss of the TREM2 gene, which is linked to increased Alzheimer's risk.