Publications by authors named "C Cirnigliaro"
Introduction: Persons with non-ambulatory spinal cord injury (SCI) undergo immediate unloading of the skeleton and, as a result, have marked loss of bone mineral density below the level of lesion that is directly associated with increased risk of long-bone fractures. There is a paucity of research that has successfully implemented rehabilitation and/or exercise training interventions to mitigate bone loss after acute SCI or reverse bone loss that has already occurred in chronic SCI. This paper describes a research protocol to compare the effect of exoskeletal-assisted walking (EAW) alone versus EAW plus transcutaneous spinal cord stimulation (EAW+tSCS) on bone density, geometry and strength in a cohort of chronic SCI participants.
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- The study investigates how robotic exoskeletons impact veterans with spinal cord injuries compared to using a regular wheelchair.
- It analyzes whether adding exoskeleton-assisted walking to standard wheelchair use leads to significant improvements in mental and physical health outcomes.
- The research was conducted as a randomized clinical trial involving 161 veteran participants across 15 Veterans Affairs medical centers over a 4-month period.
Context/objective: To identify cardiometabolic (CM) measurements that cluster to confer increased cardiovascular disease (CVD) risk using principal component analysis (PCA) in a cohort of chronic spinal cord injury (SCI) and healthy non-SCI individuals.
Approach: A cross-sectional study was performed in ninety-eight non-ambulatory men with chronic SCI and fifty-one healthy non-SCI individuals (ambulatory comparison group). Fasting blood samples were obtained for the following CM biomarkers: lipid, lipoprotein particle, fasting glucose and insulin concentrations, leptin, adiponectin, and markers of inflammation.
Article Synopsis
- Preventing lower extremity fractures is crucial for improving health outcomes in adults with chronic spinal cord injury (SCI), as these fractures significantly contribute to morbidity and mortality.
- Recent international guidelines provide best practices for screening, diagnosing, and treating low bone mass or osteoporosis in individuals with SCI, including recommendations for dietary supplements, rehabilitation techniques, and medication options.
- Effective interprofessional care is essential for managing fractures and preventing complications, emphasizing the need for timely orthopedic consultations and comprehensive rehabilitation to restore functional abilities post-fracture.
Context/objective: To describe the effect of semaglutide, a glucagon-like peptide-1 (GLP-1) agonist, to reduce body weight and improve glycemic control in overweight or obese individuals with spinal cord injury (SCI).
Design: Open-label, randomized drug intervention case series.
Setting: This study was performed at James J.