Soluble RAGE enhances muscle regeneration after cryoinjury in aged and diseased mice.

The Receptor for Advanced Glycation End Products (RAGE), classically considered a mediator of acute and chronic inflammatory responses, has recently been implicated by genetic knockout studies as a regulator of skeletal muscle physiology during development and following acute injury. Yet, the role of its soluble isoform, soluble RAGE (sRAGE), in muscle regeneration remains relatively unexplored. To address this knowledge gap, Adeno-Associated Virus (AAV) mediated and genetic knockin supplementation strategies were developed to specifically assess the effects of changing levels of sRAGE on muscle regeneration.

Marginal ulcer perforation after one anastomosis gastric bypass: a case report.

One anastomosis gastric bypass (OAGB) has gained popularity and it is currently the third most frequently performed bariatric procedure worldwide. A marginal ulcer (MU) at the anastomosis site between the gastric pouch and the small intestine is a common complication of gastric bypass procedures but a rare complication of OAGB. Risk factors for MUs include cigarette smoking, alcohol misuse, and infection.

Demonstration of therapeutic effect of plasma-synthesized polypyrrole/iodine biopolymer in rhesus monkey with complete spinal cord section.

Spinal cord injury (SCI) can cause paralysis, and although multiple therapeutic proposals have been developed in murine models, results have hardly been replicated in humans. As non-human primates (NHP) are more similar to humans than rodents, the current study investigated whether it was possible to reproduce in a NHP, the previously obtained beneficial results by using a plasma-synthesized polypyrrole/iodine (PPy/I) biopolymer, which reduce glial scar formation and inflammatory response and promotes nerve tissue preservation, regenerative processes and functional recovery in rats. In NHPs (Rhesus monkey) with SCI by complete transection (SCT) and with plasma-synthesized PPy/I application (experimental) or without (control), the expression of pro-inflammatory cytokines in blood, preservation of nervous tissue through magnetic resonance imaging and histological and morphometric techniques, regeneration through immunohistochemistry study and functional recovery through clinical examination, were evaluated.

Efficacy of a 24-month behavioral intervention focused on sugary beverage reduction for Latino mother-infant dyads: evidence from a randomized controlled trial.

Background: Childhood obesity disproportionately impacts marginalized and under-resourced communities, particularly Latinos. Although consumption of sugar-sweetened beverages and juices (SSBJs) in infancy is linked to increased obesity, few early-life interventions have targeted SSBJ reduction.

Objectives: To determine the efficacy of a culturally tailored home intervention for reducing SSBJ intake and obesity risk in Latino mothers and infants.

From Anatase TiO Nano-Cuboids to Nano-Bipyramids: Influence of Particle Shape on the TiO Photocatalytic Degradation of Emerging Contaminants in Contrasted Water Matrices.

Water pollution, resulting from industrial effluents, agricultural runoff, and pharmaceutical residues, poses serious threats to ecosystems and human health, highlighting the need for innovative approaches to effective remediation, particularly for non-biodegradable emerging pollutants. This research work explores the influence of shape-controlled nanocrystalline titanium dioxide (TiO NC), synthesized by a simple hydrothermal method, on the photodegradation efficiency of three different classes of emerging environmental pollutants: phenol, pesticides (methomyl), and drugs (sodium diclofenac). Experiments were conducted to assess the influence of the water matrix on treatment efficiency by using ultrapure water and stormwater (basic) collected from an urban drainage system as matrices.