Preliminary report on endothelial functional injury in brain arterioles of diabetic rats: in vivo observation of macromolecular transit across the vascular wall.

The coloring of longitudinal nuclei, resembling a convoy, was observed in vivo in the terminal arterioles of diabetic rat brain by means of a microcirculatory experimental model and Evans blue/albumin tracer. This emergency transit could confirm other well known passages across the vessel wall, or be considered as 'functional injury' of the diabetic endothelium, especially in case of the so-called brain-blood barrier.