Publications by authors named "C Ciacci"
One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease.
Clin Gastroenterol Hepatol
December 2024
Background & Aims: Currently, the main treatment for celiac disease (CD) is the gluten-free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome.
Methods: A total of 36 newly diagnosed patients and 36 healthy volunteers (HVs) were studied at baseline and at 12-month follow-up.
Article Synopsis
- The study investigates how fatty acids (FAs) influence inflammatory responses in celiac disease (CD) patients of different ages, revealing varying levels of certain FAs between children and adults.
- Results showed that while myristoleic acid decreased in children with CD, it increased in adults, along with elevated pro-inflammatory cytokines like IL-6 and TNF-α in both groups.
- The research suggests that targeting fatty acids might improve treatment strategies for CD by considering factors such as age, disease duration, and dietary differences.
Background: Gastroenterologists still raise concerns about adopting a non-biopsy strategy for diagnosing celiac disease (CeD) in adults.
Aim: To assess the performance of the concurrent detection of two autoantibodies targeting two independent antigens, tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP).
Methods: This prospective, multicenter, binational study collected consecutive patients with a high pre-test probability for CeD.
In an era when ecological and environmental needs and responsibilities apply pressure on the world's countries and sustainability takes centre stage, ecologic/environmental (E/E) laboratories stand as beacons of scientific inquiry, innovating, optimising, and applying various tests for a better knowledge of our natural resources and the quality status of ecosystems. The purpose of this review is to provide an overview of the use of flow cytometry (FC) as a tool for assessing environmental quality, mainly using living organisms and their biological changes as bioindicators. Cytometric approaches applied to both marine and terrestrial ecosystems ensure the detection of biochemical and functional status of the cells composing either an organ thereof or the organism itself.
View Article and Find Full Text PDFBackground: Data on resilience, the ability to recover from adversity, in coeliac disease (CeD) are lacking.
Aim: To assess the degree of resilience in patients with CeD on a gluten-free diet (GFD), and its association with clinical features, sociodemographic factors, psychological morbidity, and quality of life (QOL).
Methods: A cross-sectional multicentre Italian study was conducted on adult CeD patients between May 2022 and April 2023.