Publications by authors named "C Chunda-Liyoka"
Article Synopsis
- The PROMISE-EPI trial tested a combination of strategies to reduce HIV transmission during breastfeeding, showing better results than standard care, particularly through early diagnosis of infants and monitoring of maternal viral load.
- In Zambia, the standard care differs with more complex preventative measures, leading to an exploration of facilitators and barriers related to the new intervention to inform future implementation.
- Qualitative interviews and focus groups highlighted the benefits of integrating key intervention components for immediate action, trust in healthcare, and potential setbacks during disruptions like the COVID-19 pandemic.
Background: Sickle cell disease (SCD) is a prevalent inherited blood disorder. Globally, approximately 515 000 babies are born with SCD annually, with 75% of these births occurring in Africa. Integrating newborn screening (NBS) for SCD into primary healthcare structures, such as immunisation programmes, holds significant promise, with dried blood spots (DBS)-point-of-care technologies (POCT) like HaemoTypeSC offering cost-effective screening solutions.
View Article and Find Full Text PDFBackground: Transmission through breastfeeding accounts for more than half of the unacceptably high number of new paediatric HIV infections worldwide. We hypothesised that, in addition to maternal antiretroviral therapy (ART), extended postnatal prophylaxis with lamivudine, guided by point-of-care assays for maternal viral load, could reduce postnatal transmission.
Methods: We did a phase 3, open-label, randomised controlled trial at four health-care facilities in Zambia and four health-care facilities in Burkina Faso.
The greatest burden of sickle cell anemia (SCA) globally occurs in sub-Saharan Africa, where significant morbidity and mortality occur secondary to SCA-induced vasculopathy and stroke. Transcranial Doppler ultrasound (TCD) can grade the severity of vasculopathy, with disease modifying therapy resulting in stroke reduction in high-risk children. However, TCD utilization for vasculopathy detection in African children with SCA remains understudied.
View Article and Find Full Text PDFObjective: Our study aimed to assess the PMTCT indicators in Burkina Faso and Zambia using a patient-orientated innovative strategy based on the second visit in the Expanded Program on Immunization (EPI-2) visit at 6-8 weeks.
Design: This was a cross sectional study.
Methods: We assessed women attending EPI-2 at primary healthcare facilities in Burkina Faso and Zambia with their children about their exposure to PMTCT interventions.