Publications by authors named "C Chrelias"
Article Synopsis
- Pyometra (P) can lead to serious health issues like sepsis and multiple organ dysfunction, which are identified through the role of Toll-like receptors (TLRs) in recognizing pathogens.
- A study was conducted on 200 female mice to evaluate the effects of TLR-7 and -9 via the MYD88 pathway and the NFκB response before and after ovariohysterectomy (RP), along with any lung injuries.
- Results showed significant changes in blood chemistry and immune responses, indicating that the immune system's reaction is tied to the TLR9-MYD88 pathway, marking a notable discovery in the localization and expression of TLRs and their role in lung injury related to pyometra.
Single nucleotide polymorphisms of Toll-like receptor-4 and of autophagy-related gene 16 like-1 gene for predisposition of premature delivery: A prospective study.
Medicine (Baltimore)
October 2019
To investigate the impact of carriage of single nucleotide polymorphisms (SNPs) of the Toll-like receptor-4 (TLR4) and of autophagy-related gene 16-like-1 (ATG16L1) in preterm delivery (PTD).A prospective cohort of 145 pregnant women was studied. Women were prospectively followed-up until delivery.
View Article and Find Full Text PDFHuman Papilloma Virus has been considered as the main cause for cervical cancer. In this study we investigated epigenetic changes and especially methylation of specific sites of HPV genome. The main goal was to correlate methylation status with histological grade as well as to determine its accuracy in predicting the disease severity by establishing optimum methylation cutoffs.
View Article and Find Full Text PDFPurpose: To investigate DNA methylation changes in peripheral blood from patients with gestational diabetes mellitus (GDM) and preeclampsia (PE) due to poorly treated GDM.
Methods: Eighteen pregnant women participated in the study: 6 with GDM, 6 with PE, and 6 healthy controls. The promoter methylation status of genes was profiled using the Human Inflammatory Response and Autoimmunity EpiTect Methyl II Signature PCR Array profiles.
Problem: To study the balance of circulating heat shock protein (HSP)60 and HSP70 in pre-term delivery.
Method Of Study: A two-stage approach was used. At first stage, we run retrospective analysis of prospective collected clinical data, and at a second stage, we studied an animal model of pre-term delivery (PTD).