Publications by authors named "C Chiodi"
Article Synopsis
- Young women with breast cancer have a higher likelihood of carrying harmful BRCA gene variants, but data on tumor histology's prognostic value is limited.
- A study involving 4,628 patients revealed that lobular tumors are generally diagnosed at a later stage and are more often linked to BRCA2 mutations, while ductal tumors are frequently associated with BRCA1 mutations.
- Despite differences in tumor characteristics and treatment approaches, the study found no significant differences in disease-free or overall survival between those with ductal and lobular tumors, indicating that histology may not influence prognosis.
Background: Fatigue, cognitive impairment, anxiety, depression, and sleep disturbance are cancer-related behavioral symptoms that may persist years after early-stage breast cancer, affecting quality of life. We aimed to generate a predictive model of long-term cancer-related behavioral symptoms clusters among breast cancer survivors 4 years after diagnosis.
Methods: Patients with early-stage breast cancer were included from the CANcer TOxicity trial (ClinicalTrials.
Background: We aimed to generate a model of cancer-related fatigue (CRF) of clinical importance 2 years after diagnosis of breast cancer building on clinical and behavioral factors and integrating pre-treatment markers of systemic inflammation.
Patients And Methods: Women with stage I-III hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer were included from the multimodal, prospective CANTO cohort (NCT01993498). The primary outcome was global CRF of clinical importance [European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30 ≥40/100] 2 years after diagnosis (year 2).
Article Synopsis
- - The centromere, crucial for chromosome stability, relies on CENP-A-containing nucleosomes for proper microtubule attachment during cell division.
- - The Mis18 complex, consisting of Mis18α, Mis18β, and Mis18BP1, plays a key role in maintaining centromere identity by facilitating CENP-A loading through its specific chaperone, HJURP.
- - Research reveals the structure of the Mis18 complex and identifies key interactions needed for assembly and function, emphasizing that while Mis18α can associate with the centromere independently, Mis18β is essential for effective CENP-A loading.
Rapeseed (Brassica napus L.) is an oil-containing crop of great economic value but with considerable nitrogen requirement. Breeding root systems that efficiently absorb nitrogen from the soil could be a driver to ensure genetic gains for more sustainable rapeseed production.
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