Computerized correction of blood base excess to full hemoglobin-O saturation.

Background And Objective: A mathematical procedure was developed to obtain an accurate coefficient (-∆BE) for the correction of blood base excess to full hemoglobin-O saturation taking into account actual 2,3-diphosphoglycerate (2,3-DPG) concentration.

Methods: Previously published laboratory data were carefully processed through regression analysis, by correlating laboratory measurements of -∆BE with the corresponding values of plasma pH, CO tension and 2,3-DPG.

Results: Data processing allowed the development of two accurate fits to the original laboratory results for blood with normal 2,3-DPG and for blood depleted of 2,3-DPG (r = 0.

Erratum to "Prognostic Role of Serum Amino Acids in Head and Neck Cancer".

[This corrects the article DOI: 10.1155/2020/2291759.].

Increased ratio of P[v-a]CO to C[a-v]O without global hypoxia: the case of metformin-induced lactic acidosis.

The ratio of venoarterial CO tension to arteriovenous O content difference (P[v-a]CO/C[a-v]O) increases when lactic acidosis is due to inadequate oxygen supply (hypoxia); we aimed to verify whether it also increases when lactic acidosis develops because of mitochondrial dysfunction (dysoxia) with constant oxygen delivery. Twelve anaesthetised, mechanically ventilated pigs were intoxicated with IV metformin (4.0 to 6.

Prognostic Role of Serum Amino Acids in Head and Neck Cancer.

Introduction: Serum amino acid (AA) profiles represent a valuable tool in the metabolic assessment of cancer patients; still, information on the AA pattern in head and neck cancer (HNC) patients is insufficient. The aim of the study was to assess whether serum AA levels were associated with the stage of neoplastic disease and prognosis in primary HNC patients.

Methods: Two hundred and two primary HNC patients were included in the study.