Publications by authors named "C Chattopadhyay"
Article Synopsis
- Uveal melanoma (UM) is a serious cancer with limited treatment options, and this study investigates the effects of imipridones, which activate a protein called CLPP that can indirectly inhibit a harmful energy production process in the cancer cells.
- Researchers found that imipridones, specifically ONC201 and ONC212, reduce the growth and spread of UM cells in the lab and show promise in decreasing tumor size and increasing survival in animal models.
- The findings suggest that imipridones could be a new and effective treatment strategy for patients with metastatic uveal melanoma (mUM).
Article Synopsis
- The study explores stochastic fluid dynamics simulations near a critical endpoint related to the Ising model, with implications for quantum chromodynamics (QCD).
- It examines how shear modes interact with a conserved scalar density in model H, revealing that dynamical scaling behavior is influenced by variables like correlation length and shear viscosity.
- A crossover in the dynamical exponent from critical diffusion (z≃4) to model H's expected exponent (z≃3) is observed, and the research also investigates non-Gaussian moments of the order parameter, finding that relaxation time varies with the power n.
Purpose: Uveal melanoma (UM) is a highly aggressive disease with very few treatment options. We previously demonstrated that mUM is characterized by high oxidative phosphorylation (OXPHOS). Here we tested the anti-tumor, signaling and metabolic effects of imipridones, CLPP activators which reduce OXPHOS indirectly and have demonstrated safety in patients.
View Article and Find Full Text PDFRice (Oryza sativa) being among the most important food crops in the world is also susceptible to various bacterial and fungal diseases that are the major stumbling blocks in the way of increased production and productivity. The bacterial leaf blight caused by Xanthomonas oryzae pv. oryzae and the sheath blight disease caused by Rhizoctonia solani are among the most devastating diseases of the rice crop.
View Article and Find Full Text PDFIntroduction: After introduction of ultrasound, there is paradigm shift towards under vision performance of procedures in anaesthesia. Blind puncture and dissection of submental space may lead to vascular injury and injury to salivary glands. We describe the ultrasound guided Seldinger technique assisted submental intubation for panfacial trauma.
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