Precision of Magnetic Resonance Imaging in Detection of Anterior Cruciate Ligament and Posterior Cruciate Ligament Ruptures and Subsequent Arthroscopic Correlations: An Investigation.

 The present study endeavors to scrutinize the precision of magnetic resonance imaging as a diagnostic modality for detecting ligament disruption of the knee, with arthroscopy serving as the gold standard. The study delves into the sensitivity, specificity, positive predictive value, and negative predictive value of magnetic resonance imaging (MRI) results in a cohort of 200 patients against diagnostic arthroscopy.  Our institution conducted a comprehensive clinical examination of all patients with knee injuries, and those with affirmative findings suggestive of ligament disruption were subjected to an MRI scan.

A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics.

Polymorphisms of Thiopurine S-methyltransferase (TPMT) are known to be associated with leukemia, inflammatory bowel diseases, and more. The objective of the present study was to identify novel deleterious missense SNPs of TPMT through a comprehensive in silico protocol. The initial SNP screening protocol used to identify deleterious SNPs from the pool of all TPMT SNPs in the dbSNP database yielded an accuracy of 83.

Community-based interventions for detection and management of diabetes and hypertension in underserved communities: a mixed-methods evaluation in Brazil, India, South Africa and the USA.

Introduction: As non-communicable disease (NCD) burden rises worldwide, community-based programmes are a promising strategy to bridge gaps in NCD care. The HealthRise programme sought to improve hypertension and diabetes management for underserved communities in nine sites across Brazil, India, South Africa and the USA between 2016 and 2018. This study presents findings from the programme's endline evaluation.

Estimation of serum neopterin level as an early marker for detecting severe dengue infection.

Background: This study aimed to determine the role of neopterin in the early assessment of dengue severity in children of age one month to 18 years admitted for fever and confirmed by dengue serology.

Method: Two sets of samples were collected from 77 confirmed dengue patients aged one month to 18 years for serum neopterin determination. The first sample was collected at 2-3 days of fever onset, and the second sample was collected at 24-36 h after the first sample was collected and followed up cases and correlated serum neopterin levels.