Redox-Active Triphenylamine-Triazine Covalent Organic Framework: A High Surface Area Microporous Material for Electrochromism and Electrofluorochromism.

Porous covalent organic frameworks (COFs) offer significant advantages in electrochromic (EC) applications due to their high surface area and porosity, which facilitate faradaic redox-mediated diffusion-controlled processes. However, COFs remain underexplored as EC materials due to challenges such as limited solubility and poor film-forming ability. In this study, we synthesized a redox-active triphenylamine-containing COF (TPA-TCIF) on ITO glass via a solvothermal method tailored for electrochromism and electrofluorochromism.

Prompt engineering-enabled LLM or MLLM and instigative bioinformatics pave the way to identify and characterize the significant SARS-CoV-2 antibody escape mutations.

The research aims to identify and characterize the antibody escape mutations of NTD and RBD regions of SARS-CoV-2 using prompt engineering-enabled combined LLMs (large language models) and instigative bioinformatics techniques. We used two LLMs (ChatGPT and Mistral 7B) and one MLLM (Gemini model) to retrieve the significant NTD and RBD mutations. The retrieved significant mutations were characterized through the in silico servers.

The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis.

Toll-like receptors (TLRs) of human are considered as the most critical immunological mediators of inflammatory pathogenesis of COVID-19. These immunoregulatory glycoproteins are located on the surface and/or intracellular compartment act as innate immune sensors. Upon binding with distinct SARS-CoV-2 ligand(s), TLRs signal activation of different transcription factors that induce expression of the proinflammatory mediators that collectively induce 'cytokine storm'.

Mapping the Potential Genes and Associated Pathways Involved in Long COVID-Associated Brain Fog Using Integrative Bioinformatics and Systems Biology Strategy.

One of the recent emerging global health issues is long COVID. Among long COVID patients, long COVID-associated brain fog is an important area. We noted an immense gap in understanding the genes and associated pathways involved in long COVID-associated brain fog.

CAD-PsorNet: deep transfer learning for computer-assisted diagnosis of skin psoriasis.

Psoriasis, being a chronic, inflammatory, lifelong skin disorder, has become a major threat to the human population. The precise and effective diagnosis of psoriasis continues to be difficult for clinicians due to its varied nature. In northern India, the prevalence of psoriasis among adult population ranges from 0.