Independent evaluation of tolerance of therapeutic plasma inactivated by amotosalen-HCl-UVA (Intercept ™) over a 5-year period of extensive delivery.

Amotosalen-HCl-UVA (AI) is a process to inactivate pathogens in therapeutic plasma (FFP). Tolerance is the main residual issue in FFP transfusion, and only large series observations are powered enough to identify significantly elevated levels of hazards. We report here on 15,133 new transfusions of AI-FFP, over the previously published 36,035, which in all represents one of the largest series observed by means of a highly standardized surveillance (51.

[For early treatment of Class II div 1 malocclusions].

Should treatment of a Class II div. 1 malocclusion begin in the early, in mixed dentition or later in the adolescent dentition? In a Cochrane review, the authors conclude: "The evidence suggests that providing early orthodontic treatment for children with prominent upper front teeth is no more effective than providing one course of orthodontic treatment when the child is in early adolescence." So, should you wait to treat ? Certainly not ! Many arguments in favor of early treatment are: reduction of the risk of fracture of prominent incisors, esthetic factors, increase in patient self-esteem and reduction of negative social experiences, reduction of the length of fixed appliance therapy thereby reducing possible iatrogenic effects, creating an environment more favorable to harmonious growth and development, without forgetting the legal concept of loss of opportunity.

[Pediatric transfusion practices: A single-center retrospective study].

Objectives: This study aimed to describe the professional practices in pediatric transfusion to assess the accuracy of transfusion guidelines in children.

Methods: The study retrospectively analyzed the characteristics of all the pediatric transfusions prescribed in the Clermont-Ferrand (France) university hospital center over 1 year and determined whether they conformed to the national guidelines.

Results: One thousand six hundred and seven blood products were delivered to 233 children (806 red cell units, 670 platelet units, and 131 plasma units), accounting for 5.

[Evaluation of continuous education in transfusion for professionals in medical blood banks].

Purpose Of The Study: Like every actor in transfusion, staff members practising within blood banks of healthcare establishments have to follow a specific initial training and must frequently update their knowledge in blood transfusion.

Methods: To address this need from these professionals, the Établissement français du sang Auvergne-Loire set up training sessions which content regularly evolved according to regulation recommendations. Every cycle consists in a total of 35hours of training, divided in five one-day modules.

[Known gene interactions as implicated in craniofacial development].

Many genes intervening in development, morphogenesis and craniofacial growth have been identified, primarily by the use of mice mutants. We can distinguish two families: the signalling factors and the transcription factors. The latter interact with DNA to activate or to inhibit the expression of other genes.