Do MSI-L sporadic colorectal tumors develop through "mild mutator pathway"?

Background: The mutator pathway implied in the development of colorectal cancer (CRC) is characterized by microsatellite instability (MSI). MSI tumors can be subdivided according to the level of instability: MSI-H (high), MSI-L (low) or stable MSS. MSI-H CRC displays a well described distinct phenotype, but the true biologic significance of MSI-L is still uncertain.

Dehiscence of gastrojejunal stapled anastomosis after lithotripsy for nephrolithiasis.

We report the case of a 76-year-old woman with previous bariatric surgery and a large renal calculus following a prolonged lithotripsy session. The patient presented with peritonitis due to dehiscence of the gastrojejunal stapled anastomosis.