Publications by authors named "C Cefalo"
Background And Aims: Impaired myocardial mechano-energetic efficiency (MEE) has been associated with cardiac insulin resistance measured by dynamic positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) combined with euglycemic-hyperinsulinemic clamp. Estimate glucose disposal rate (eGDR) index has a good correlation with whole-body insulin sensitivity. It remains unsettled whether eGDR index is a suitable proxy of cardiac insulin sensitivity as well as its association with myocardial MEE.
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- The International Diabetes Federation recommends using 1-hour plasma glucose (1-hPG) during oral glucose tolerance tests to diagnose intermediate hyperglycemia (IH) and type 2 diabetes (T2DM).
- A study involving 3086 individuals classified them into four groups based on glucose tolerance levels, revealing notable differences in cardiometabolic traits.
- Results show that those with IH and T2DM have worse indicators such as higher body fat, blood pressure, and poorer insulin sensitivity compared to those with normal glucose tolerance and isolated impaired fasting glucose.
Article Synopsis
- The study aims to use the estimated glucose disposal rate (eGDR) to differentiate between healthy and unhealthy metabolic profiles based on waist circumference, hypertension, and glycated hemoglobin.
- Researchers assessed nearly 2,201 non-diabetic individuals by grouping them according to their eGDR scores, categorizing them into healthy and unhealthy weight classifications.
- Results indicate that individuals with a metabolically healthy profile have lower instances of impaired fasting glucose and glucose tolerance, regardless of their weight, compared to those with metabolically unhealthy classifications.
Objective: Reduced myocardial mechano-energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with "metabolically healthy overweight" (MHOW) and "metabolically healthy obesity" (MHO), respectively. We aim to investigate whether those with MHOW/MHO, defined as those having none of the components of metabolic syndrome, exhibit impaired MEE compared with their unhealthy counterparts.
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- The study investigates the link between plasma levels of asymmetric dimethylarginine (ADMA) and myocardial mechano-energetics efficiency (MEEi) in drug-naïve hypertensive individuals.
- It involved 63 hypertensive participants who had their myocardial MEEi measured through echocardiograms, while ADMA levels were analyzed using high-performance liquid chromatography.
- Results showed a significant negative association between ADMA levels and MEEi, suggesting that higher ADMA may reduce nitric oxide availability and thus lower myocardial efficiency, independent of other cardiovascular risk factors.