Selective cyclooxygenase 2 inhibition lowers spinal cord prostaglandin concentrations after injury.

Background Context: Prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) concentrations are elevated in the injured spinal cord for hours to days after injury. Treatment of animals with a selective cyclooxygenase-2 (COX-2) inhibitor has been shown to improve functional outcome in an animal model.

Purpose: We sought to characterize the effects of COX-2 inhibition on prostaglandin concentrations in the spinal cord after injury.

Regional and temporal changes in prostaglandin E2 and thromboxane B2 concentrations after spinal cord injury.

Background Context: Inflammatory metabolites of arachidonic acid likely play a significant role in secondary injury after spinal cord trauma.

Purpose: We sought to characterize the regional and temporal alterations in prostaglandin concentrations after injury in a rat model.

Study Design/setting: Prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) concentrations were measured in cerebrospinal fluid (CSF) and in different parts of the injured spinal cord at various time points after spinal cord injury.

Adult olfactory ensheathing cell transplantation for acute spinal cord injury.

Cellular transplantation strategies have been explored for the treatment of spinal cord injury. In particular, olfactory nerve ensheathing cell (OEC) transplantation has been reported to improve functional outcome following injury. We investigated the effect of OEC transplantation using cells derived from adult animals on the restoration of function following a contusion injury to the spinal cord.

GeneChip analysis after acute spinal cord injury in rat.

Spinal cord injury (SCI) leads to induction and/or suppression of several genes, the interplay of which governs the neuronal death and subsequent loss of motor function. Using GeneChip, the present study analyzed changes in the mRNA abundance at 3 and 24 h after SCI in adult rats. SCI was induced at T9 level by the New York University impactor by dropping a 10-g weight from a height of 25 mm.