Publications by authors named "C Catarino"
In alignment with the global movement toward reducing animal testing, several reconstructed human epidermis (RHE) models have been created for conducting skin irritation tests. These models have undergone development, verification, validation, and integration into OECD TG 439. Our team has introduced a novel in-house RHE named GB-RHE, and we adhere to OECD TG 439 to pre-validate the model and test its potential employment for nanoparticle irritation studies.
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- * In studies using a mouse model lacking the NPC1 protein in immune cells, researchers found significant changes in microglial lipid profiles, increased microglial activity, and symptoms resembling NPC disease, such as lifespan reduction and motor issues.
- * Monitoring translocator protein (TSPO) levels in the blood may be useful for assessing NPC disease progression and treatment response, as shown by changes in TSPO levels following a specific therapy that appeared beneficial for patients.
Article Synopsis
- Over the years, treatment for people with hemophilia has gotten a lot better because of new scientific discoveries.
- Despite these improvements, there are still some limits to the treatments that make us want to keep finding new options.
- The goal is to make sure everyone with hemophilia, no matter their age or how severe it is, can get treatments that stop bleeding and let them live full lives.
Atherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability; effective cardiovascular (CV) risk prevention is fundamental. The World Heart Federation (WHF) Cholesterol Roadmap provides a framework for national policy development and aims to achieve ASCVD prevention. At the invitation of the WHF, a group of experts from the Portuguese Society of Cardiology (SPC), addressed the cholesterol burden at nationally and discussed possible strategies to include in a Portuguese cholesterol roadmap.
View Article and Find Full Text PDFWe aimed to study the impact of polymorphisms in the genes encoding interleukin-6 (IL6) and tumor necrosis factor receptor-2 (TNFR2), reported to be mortality risk predictors, in patients with end-stage kidney disease (ESKD) undergoing dialysis. (rs3397, rs1061624, and rs1061622) and (rs1800796, rs1800797, and rs1554606) polymorphisms were studied in patients with ESKD and controls; the genotype and allele frequencies and the associations with inflammatory and erythropoiesis markers were determined; deaths were recorded throughout the following two years. The genotype and allele frequencies for the rs3397 polymorphism were different in these patients compared to those in the controls and the global and European populations, and patients with the C allele were less common.
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