Publications by authors named "C Casserly"
New insights into the use of high dose corticosteroids and plasmapheresis in persons with MOGAD and NMOSD.
Mult Scler Relat Disord
December 2024
Background: Anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD) and neuromyelitis optica spectrum disease (NMOSD) are antibody mediated diseases characterized by neurological symptoms including recurrent relapses of optic neuritis and/or myelitis, as well as other less frequent syndromes. The current treatment for acute attacks of NMOSD/MOGAD are based on clinical studies for other demyelinating diseases(i.e.
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- Cognitive impairment (CI) is common in people with multiple sclerosis (PwMS) and may be more closely linked to depression than to actual cognitive performance, making self-reports of CI potentially unreliable.
- This study aims to explore how employment status affects cognitive testing performance and to determine the complex interactions between self-reported CI, depression, and cognitive abilities in PwMS.
- A retrospective analysis of 590 PwMS was conducted using various validated questionnaires and structural equation modeling to assess the relationships between self-reported cognition, employment status, and cognitive performance outcomes like memory and processing speed.
Background: Cognitive impairment (CI) is common in multiple sclerosis (MS), affecting half of persons with MS (PwMS). Cognitive reserve has been associated with delaying the onset and slowing the progression of CI in PwMS. Multilingualism has been demonstrated to be a protective factor against CI in Alzheimer's disease (AD) but has never been studied in PwMS.
View Article and Find Full Text PDFBackground: Myelopathies require prompt etiologic diagnosis. We aimed to identify a specific myelopathy diagnosis in cases of suspected myelitis to highlight clinicoradiologic differences.
Methods: In this retrospective, single-centre cohort of subjects with suspected myelitis referred to London Multiple Sclerosis (MS) Clinic between 2006 and 2021, we identified those with MS and reviewed the remaining charts for etiologic diagnosis based on clinical, serologic, and imaging details.