Publications by authors named "C Casali"
Background: Cranial vault lesions are common in children, with dermoid and epidermoid cysts being the most frequent. Management is debated due to their slow growth, but early resection can prevent complications and provide a definitive histological diagnosis, which is sometimes linked to systemic diseases.
Methods: A retrospective study of children treated surgically for cranial vault tumors from January 2011 to April 2023 was conducted.
As nanocarriers of a new generation, biomimetic nanovesicles are an emerging class of therapeutic tools whose surface is integrated or fabricated with biomaterials capable of mimicking the biological features and functions of native cells. Thanks to this, biomimetic nanovesicles, in particular, those made by plasma membrane moieties, possess greatly improved biocompatibility, high target specificity, a long retention time, and minimal undesired immune responses. For these reasons, a multitude of progenitor cells including cancer ones were employed as templates to generate biomimetic or membrane-camouflaged nanovesicles hosting different therapeutic compounds.
View Article and Find Full Text PDFBackground: Facioscapulohumeral dystrophy (FSHD) is a myopathy characterized by the loss of repressive epigenetic features affecting the D4Z4 locus (4q35). The assessment of DNA methylation at two regions (DUX4-PAS and DR1) of D4Z4 locus proved to be an effective method to detect epigenetic signatures compatible with FSHD. The present study aims at validating the employment of this method into clinical practice and improving the protocol by refining the classification thresholds of 4qA/4qA patients.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how calcium (Ca) transfer between the endoplasmic reticulum (ER) and mitochondria, crucial for energy production, is affected by the distance between these organelles, particularly in the context of Parkinson's disease (PD).
- - Researchers found that a specific distance of approximately 20 nm between ER and mitochondria enhances Ca transfer and supports optimal mitochondrial function, highlighting the importance of maintaining this distance.
- - In astrocytes derived from PD patients, the natural distance for efficient Ca transfer was reduced, leading to decreased mitochondrial function, but restoring the 20 nm distance improved Ca uptake, suggesting new ways to manage mitochondrial health.