Publications by authors named "C Carthy"
Article Synopsis
- Neuronal activity in the nucleus accumbens core (NAcore) is essential for behaviors associated with seeking rewards, and the study explores how this activity relates to drug addiction.
- Researchers used advanced imaging techniques on specific neurons in mice to compare how these neurons responded to natural rewards like sucrose versus drug rewards such as cocaine, particularly during reward-seeking behavior.
- The results indicated that dopamine D1-receptor-expressing neurons in cocaine-trained mice showed consistent activity patterns that were linked to both reward-seeking and cue-induced cravings, suggesting that these neurons play a critical role in prioritizing drug seeking over natural rewards in substance use disorders.
Impairments in social behavior are observed in a range of neuropsychiatric disorders and several lines of evidence have demonstrated that dysfunction of the prefrontal cortex (PFC) plays a central role in social deficits. We have previously shown that loss of neuropsychiatric risk gene that codes for the Ca1.2 isoform of L-type calcium channels (LTCCs) in the PFC result in impaired sociability as tested using the three-chamber social approach test.
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- Social hierarchies significantly influence behavior, but the brain mechanisms behind this are not fully understood, particularly at the neural circuit level.
- Researchers used advanced methods to study the activity of specific brain cells in the ventromedial prefrontal cortex (vmPFC) during social competition among mice.
- Findings indicate that these brain cells signal learned social rankings and are crucial for subordinate mice when displaying social behaviors, especially after experiencing social stress, highlighting their role in managing social interactions based on past experiences.
The importance of electron deficient Tp ligands motivates the introduction of electron-withdrawing substituents into the scorpionate framework. Since perfluorophenyltris(pyrazol-1-yl)borate affects significant anodic shifts in half-cell potentials in their metal complexes relative those of phenyltris(pyrazol-1-yl)borate analogues, the tuning opportunities achieved using 3,4,5-trifluorophenyl- and 3,5-bis(trifluoromethyl)phenyl(pyrazol-1-yl)borates were explored. Bis(amino)boranes ((3,4,5-F)CH)B(NMe) and ((3,5-CF)CH)B(NMe) are precursors to fluorinated tris(pyrazol-1-yl)phenylborates.
View Article and Find Full Text PDFBackground: Transsphenoidal surgery (TSS) to resect an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma is the first-line treatment for Cushing's disease (CD), with increasing usage of endoscopic transsphenoidal (ETSS) technique. The aim of this study was to assess remission rates and postoperative complications following ETSS for CD.
Methods: A retrospective analysis of a prospective single-surgeon database of consecutive patients with CD who underwent ETSS between January 2012-February 2020.