Publications by authors named "C Carlucci"

Inflammation is pathogenic to skin diseases, including atopic dermatitis (AD) and eczema. Treatment for AD remains mostly symptomatic with newer but costly options, tainted with adverse side effects. There is an unmet need for safe therapeutic and preventative strategies for AD.

View Article and Find Full Text PDF
Article Synopsis
  • Recent advancements in pediatric oncology drug development have led to innovative therapies and clinical trial approaches, though new drug approvals remain slow.
  • Regulatory changes in the US and Europe have increased the urgency for faster drug development tailored to pediatric patients with cancer.
  • The iMATRIX platform showcases a new trial framework that studies multiple drugs for various pediatric tumor types simultaneously, with six studies currently conducted or planned to test different treatment options.
View Article and Find Full Text PDF

 The aim of the study is to describe the real-world use of the P2Y inhibitor cangrelor as a bridging strategy in patients at high thrombotic risk after percutaneous coronary intervention (PCI) and referred to surgery requiring perioperative withdrawal of dual antiplatelet therapy (DAPT).  We collected data from nine Italian centers on patients with previous PCI who were still on DAPT and undergoing nondeferrable surgery requiring DAPT discontinuation. A perioperative standardized bridging protocol with cangrelor was used.

View Article and Find Full Text PDF

A synthesis of unprecedented and stable glycosyl sulfoximines is reported. The developed strategies represent the first example of highly stereoselective sulfoximine formation directly from thioglycosides. This synthetic protocol has been tested on several β-thioglycosides bearing different aromatics and alkyls as S-substituents, and bearing glucose, mannose and galactose as glycosyl units.

View Article and Find Full Text PDF

A new synthetic route to -alkyl-2-acylazetidines was developed through a highly stereoselective addition of organolithiums to -alkyl-2-oxazolinylazetidines followed by acidic hydrolysis of the resulting oxazolidine intermediates. This study revealed an unusual reactivity of the C=N bond of the oxazoline group when reacted with organolithiums in a non-polar solvent such as toluene. The observed reactivity has been explained considering the role of the nitrogen lone pair of the azetidine ring as well as of the oxazolinyl group in promoting a complexation of the organolithium, thus ending up with the addition to the C=N double bond.

View Article and Find Full Text PDF