Publications by authors named "C Carlos"
Article Synopsis
- High-dose methotrexate (MTX) can lead to serious complications like acute kidney injury (AKI), neutropenia, and liver damage, but glucarpidase, an enzyme that breaks down MTX, shows potential benefits.
- In a study of 708 patients with MTX-AKI across 28 cancer centers, those receiving glucarpidase had a significantly higher chance of kidney recovery and faster recovery times compared to those who did not receive the treatment.
- Additionally, glucarpidase treatment was associated with lower rates of severe neutropenia and liver enzyme elevation, but there was no notable difference in mortality rates between the two groups.
Oxidative Stress, Lysosomal Permeability, and Mitochondrial-Derived Vesicles Induced in NL-20 Human Bronchial Cells Exposed to Benzo[ghi]Perylene.
López-Pérez Lizardo Roldán-Barreto Elisa Xochiteotzin-Reyes Tania Torres-Flores Ulises Licea-Quintero Brandon Corona Juan Carlos
Toxicol In Vitro
December 2024
Benzo[ghi] perylene (b[ghi]p) is classified as non-carcinogenic to humans, and there are currently no occupational exposure models available to identify its effects. The aim of this work was to evaluate the effect of b[ghi]p on the lysosomes of NL-20 cells (a human bronchial cell line) exposed to 4.5 μM for 3 h.
View Article and Find Full Text PDFBackground: One of the causes of low back pain can be directly related to mechanical stability. Stability is the result of coordinated muscle patterns. One of the clinical tests used to assess the pattern of muscle activation is the hip extension test in the prone position, which is considered a reliable test to evaluate lumbopelvic stability.
View Article and Find Full Text PDFArticle Synopsis
- * It compared placental samples from three groups: women without diabetes, those with gestational diabetes, and those with a history of diabetes, analyzing their glycemic control and vessel characteristics.
- * Findings revealed that women with gestational or previous diabetes had altered vessel characteristics, including a reduction in the number and area of vessels, indicating that high blood sugar can impact placental blood supply.
Article Synopsis
- The study investigates whether intensive blood pressure (BP) control can be safely achieved for patients with advanced chronic kidney disease (CKD) using remote monitoring and medication adjustment.
- In a pilot randomized trial involving 108 patients with advanced CKD and hypertension, participants were assigned to either a lower target systolic BP (<120 mmHg) or a less intensive target.
- Results showed that the intensive BP group achieved a significantly lower mean clinic systolic BP without a notable increase in safety risks, though the small sample size raises questions about the robustness of the findings.