Evaluating inter- and intra-rater reliability in assessing upper limb compensatory movements post-stroke: creating a ground truth through video analysis?

Background: Compensatory movements frequently emerge in the process of motor recovery after a stroke. Given their potential for unfavorable long-term effects, it is crucial to assess and document compensatory movements throughout rehabilitation. However, clinically applicable assessment tools are currently limited.

The response of hepatic acute phase proteins during experimental pulmonary tuberculosis.

A mouse model of pulmonary tuberculosis induced by the intratracheal instillation of live and virulent mycobacteria strain H37-Rv was used to study the relationship of the histopathological changes with the kinetics of local production and circulating levels of interleukin 6 (IL-6) and the gene expression of acute phase proteins (APP) in the liver. The histopathological studies showed a mononuclear inflammatory infiltrate located in the perivascular, peribronchial, and interstitial areas, with granulomas which started to form 2 weeks after the infection. Numerous IL-6 immunostained activated macrophages were observed in the inflammatory infiltrate, particularly in the interstitial-intralveolar compartment and granulomas, coexisting with a high IL-6 mRNA concentration determined by reverse transcription polimerase chain reaction in lung homogenates, particularly at day 21 of infection.