Publications by authors named "C Cantarelli"
This report describes the decision-making, surgical management, and rehabilitation plan for an amputation at the level of the proximal radius in a 75-kilogram goat. The information provided in our report may aid veterinarians in educating and reassuring pet-goat owners about the different aspects involved with amputation, helping to better inform their decisions for the associated intensive postoperative care and rehabilitation time. Key clinical message: Amputation of a front limb in a large-sized goat can be perceived by pet-goat owners as a positive outcome and associated with good quality of life.
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- Patients with autosomal dominant polycystic kidney disease (ADPKD) exhibit complement activation, but its role in kidney cyst growth was previously unclear.
- Research using a specific cell line and genetically modified mice showed that lack of the Pkd1 gene leads to increased complement-related genes and faster cyst formation, while its absence delayed cyst growth and reduced inflammation.
- The study suggests that the downregulation of complement regulators due to Pkd1 loss enhances cystogenesis through C5a activation, indicating a potential new target for therapeutic interventions in ADPKD.
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- The study investigates the effects of naturally occurring erythropoietin (EPO) on immune function in mice, specifically its role in regulating lupus.
- Researchers created a mouse model to reduce EPO production and assessed immune responses over time, including antibody levels and disease severity.
- Findings reveal that lower EPO levels led to increased autoantibodies and disease severity in lupus, suggesting that EPO plays a protective role in maintaining immune balance.
Article Synopsis
- In a mouse model of membranous nephropathy (MN) caused by cationic bovine serum albumin (cBSA), the complement regulator decay-accelerating factor (DAF) is increased to control complement activation.
- Research shows that the activation of complement primarily occurs through C3a/C3aR signaling, making these pathways potential targets for new treatments for MN.
- Experiments revealed that without DAF, there was more complement activation and disease severity increased, but blocking C3aR in DAF mice reduced MN severity, highlighting the significant role of complement in the disease's progression.