Publications by authors named "C Camisaschi"
NK cells are endowed with tumor killing ability, nevertheless most cancers impair NK cell functionality, and cell-based therapies have limited efficacy in solid tumors. How cancers render NK cell dysfunctional is unclear, and overcoming resistance is an important immune-therapeutic aim. Here, we identify autophagy as a central regulator of NK cell anti-tumor function.
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- Alloreactive T-cell responses can lead to graft-versus-host disease (GVHD) after allogeneic stem cell transplants, negatively impacting patient health by causing increased morbidity and mortality.
- However, these T-cells can also target remaining tumor cells in a beneficial way, contributing to the graft-versus-tumor effect (GVT) which helps prevent cancer relapse.
- The text discusses a method for identifying alloreactive naïve and memory T cells through co-culturing with antigen-presenting cells, using a CFSE dilution technique to track activation, which can then be analyzed for further research.
Article Synopsis
- Parkin, an E3 ubiquitin ligase linked to Parkinson's Disease, is epigenetically silenced in cancer but can be reactivated by demethylating therapies, leading to a strong interferon (IFN) response in tumor cells.* -
- This reactivation involves Parkin's E3 ligase activity, facilitating the release of the alarmin HMGB1 and inhibiting NF-κB gene expression, which collectively enhances the immune response.* -
- Parkin reexpression promotes CD8+ T cell activation and accumulation in the tumor environment, ultimately suppressing tumor growth and highlighting Parkin's role as both an immune activator and tumor suppressor.*
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- CD8 T cells are crucial for controlling tumors but often become dysfunctional in the tumor environment; sodium chloride (NaCl) has been found to counteract this dysfunction and promote cancer regression.
- Supplementing NaCl during CD8 T cell culture enhances their activation and effectiveness while preserving key gene networks associated with T cell plasticity, leading to improved anti-tumor responses in mouse models.
- The research suggests that NaCl affects CD8 T cell function by boosting their glutamine consumption, which is essential for their overall effectiveness, indicating potential new strategies for enhancing cancer immunotherapy in humans.
Article Synopsis
- Skeletal Stem Cells (SSCs) are crucial for bone development and repair, and the cytokine RANKL plays an important role in their regulation, making it a key focus for research in regenerative medicine.
- In experiments with mice lacking RANKL, researchers found that SSCs had a higher frequency but showed impaired ability to differentiate into bone-forming cells, indicating the significance of RANKL in SSC functionality.
- Additionally, treating human bone marrow-derived stromal cells with the anti-RANKL antibody Denosumab resulted in decreased osteogenic potential, highlighting the potential impact of RANKL modulation on bone health.