Publications by authors named "C Cahir"
Purpose: Older people are at an increased risk of developing adverse drug reactions (ADR) and adverse drug events (ADE). This study aimed to develop and validate a risk prediction model (ADAPTiP) for ADR/ADE in older populations.
Methods: We used the adverse drug reactions in an Ageing PopulaTion (ADAPT) cohort (N = 798; 361 ADR-related admissions; 437 non-ADR-related admissions), a cross-sectional study designed to examine the prevalence and risk factors for ADR-related hospital admissions in patients aged ≥ 65 years.
Background: Drug-drug interactions (DDIs), highly prevalent amongst the elderly, can lead to avoidable medication-related harm. Cardiovascular and central nervous system (CNS) drugs are commonly implicated. To date, there is no consensus on how to measure DDIs, making comparisons across countries challenging.
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- Adverse drug reactions (ADRs) are prevalent, particularly in older adults, leading to serious health issues and high healthcare costs, prompting a need for better prediction models.* -
- A systematic review included eight studies on ADR-risk prediction tools for older adults, finding mixed results in their reliability and poor adherence to established reporting guidelines (TRIPOD).* -
- The findings indicate a need for improved prediction models that are both validated and practical for real-world application to better assess their effectiveness and usability.*
Article Synopsis
- Ovarian function suppression (OFS) using gonadotropin-releasing hormone agonists (GnRHas) is a common treatment for premenopausal patients with high-risk hormone receptor-positive breast cancer, but there is limited guidance on its optimal use.
- A survey sent to oncologists revealed that most used goserelin and leuprolide as GnRHas, with varied practices around initiation and duration of therapy, and inconsistent monitoring of estradiol levels.
- The results showed significant variation in treatment approaches among oncologists, and a strong desire (92%) for more practical guidance from ASCO on OFS management.
Background: Assessment of comprehensive consultations in medicine, i.e. a complete history, physical examination, and differential diagnosis, is regarded as authentic tests of clinical competence; however, they have been shown to have low reliability and validity due to variability in the real patients used and subjective examiner grading.
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