Publications by authors named "C Cadena-Cruz"
Article Synopsis
- Three unsymmetrical 7-(diethylamino)quinolone chalcones were created through a Claisen-Schmidt reaction, utilizing 7-(diethylamino)quinolone and vanillin as electron donors linked by an α,β-unsaturated carbonyl as the electron acceptor.
- The photophysical analysis showed significant Stokes shifts and solvatofluorochromism due to intramolecular charge transfer (ICT) and twisted intramolecular charge transfer (TICT), with density functional theory (DFT) calculations supporting these findings.
- Cytotoxic tests on various cancer cell lines showed moderate activity, particularly against LNCaP cells, and the compounds demonstrated potential as imaging agents with strong emission and good cell permeability,
Background: Respiratory Syncytial Virus (RSV) presents a significant health threat, especially to young children. In-depth understanding of RSV entry mechanisms is essential for effective antiviral development. This study introduces an innovative RSV variant, featuring the fusion of the beta-lactamase (BlaM) enzyme with the RSV-P phosphoprotein, providing a versatile tool for dissecting viral entry dynamics.
View Article and Find Full Text PDFRespiratory syncytial virus (RSV) is a virus that causes acute respiratory infections in neonates and older adults. To infect host cells, the attachment glycoprotein (G) interacts with a cell surface receptor. This interaction determines the specific cell types that are susceptible to infection.
View Article and Find Full Text PDFHIV infection has a tremendous impact on the immune system's proper functioning. The mucosa-associated lymphoid tissue (MALT) is significantly disarrayed during HIV infection. Compositional changes in the gut microbiota might contribute to the mucosal barrier disruption, and consequently to microbial translocation.
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