Publications by authors named "C Cade"
Article Synopsis
- * A study at Ochsner LSU Health examined the types of bacteria found in infected DFUs of 115 patients and the antibiotics used, noting a high occurrence of gram-negative bacteria and a significant rate of acute kidney injury (AKI) linked to current treatment practices.
- * The findings suggest a mismatch between the microbial profiles of these infections and the antibiotics typically prescribed, emphasizing the need for treatment strategies that focus on gram-negative bacteria and reduce risk of kidney damage.
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View Article and Find Full Text PDFCaspases have several allosteric sites that bind small molecules or peptides. Allosteric regulators are known to affect caspase enzyme activity, in general, by facilitating large conformational changes that convert the active enzyme to a zymogen-like form in which the substrate-binding pocket is disordered. Mutations in presumed allosteric networks also decrease activity, although large structural changes are not observed.
View Article and Find Full Text PDFContinuous amoxicillin infusion for deep infection's intravenous treatment is performed using elastomeric portable pumps carried under clothing and requires high doses of antibiotic. Therefore, we evaluated the stability of amoxicillin in those medical devices, with particular focus on both drug concentration and storage temperature. Stability of 20, 40, and 60g/L amoxicillin solutions in 300 mL portable pumps stored at 20 or 35 degrees C was studied by visual examination and drug concentration measurements at T0; T0 + 12 h; T0 + 24 h and; T0 + 48 h.
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