Understanding the (Brine Shrimp) Test: Pharmacological Significance and Global Impact.

Background: The microplate benchtop brine shrimp test (BST) has been widely used for screening and bio-guided isolation of many active compounds, including natural products. Although the interpretation given to the results appears dissimilar, our findings suggest a correlation between positive results with a specific mechanism of action.

Objective: This study aimed to evaluate drugs belonging to fifteen pharmacological categories having diverse mechanisms of action and carry out a bibliometric analysis of over 700 citations related to microwell BST.

Pharmacognostic Evaluation of Ten Species of Medicinal Importance of Cecropia: Current Knowledge and Therapeutic Perspectives.

This work covers a systematic review of literature about the genus from 1978 to 2020, emphasizing the analysis of 10 of the most relevant species and their associated biological activities. is a neotropical genus, which comprises about 61 native species in the American continent where it is known to be part of the traditional medicine of numerous countries. Secondary metabolites described for this genus showed an elevated structural and functional diversity, where polyphenols have been the most abundant.

Validation of an UPLC-DAD Method for the Quantification of Phenolic Acids, Verbascoside and 6-epi-aucubin in Crescentia cujete Fruit.

Background: The fruit pulp decoction of Crescentia cujete, commonly known as calabash, is traditionally used for the treatment of several respiratory diseases and is available as syrup formulations. Unfortunately, there is no detailed investigation on the analytical methods for warranting the quality of these products.

Aims And Objectives: To develop and validate an appropriate analytical method for the simultaneous quantification of trans-cinnamic acid, 4-hydroxybenzoic acid, verbascoside and 6- epi-aucubin in the decoction and commercial cough syrups of Crescentia cujete fruit.