Publications by authors named "C CHARDOT"
Article Synopsis
- Short Bowel Syndrome (SBS) is a significant cause of intestinal failure in children, and this study evaluates the long-term outcomes of the surgical technique called serial transverse enteroplasty (STEP) used to treat it.
- The study involved a review of 36 children who underwent STEP between 2000 and 2022, examining their medical histories, surgical details, and nutritional support.
- Results showed an increase in bowel length and a decrease in dependency on parenteral nutrition, with many children experiencing improved digestive symptoms and growth after the procedure, indicating STEP can be a beneficial option for managing SBS in children.
Aims: To report the results and successes of intestinal transplantation (ITx) in the most active European centres, to emphasize that, although it is a difficult procedure, it should remain a therapeutic option for children with total, definitive and complicated intestinal failure when intestinal rehabilitation fails.
Methods: We retrospectively collected data about all patients less than 18 receiving an ITx from 2010 to 2022 in 8 centres, and outcomes in July 2022.
Results: ITx was performed in 155 patients, median age 6.
Article Synopsis
- Hepatoblastomas show varied cell types that affect patient outcomes, but the reasons for this diversity are not well understood.
- Researchers employed a single-cell analysis to explore the molecular factors contributing to these different cell states, revealing a spectrum of differentiation between liver cell types.
- They discovered that specific genetic subclones within tumors exhibit unique levels of cellular flexibility, with certain subclones being more aggressive and responsive to chemotherapy due to the overexpression of specific genes.
Article Synopsis
- About 5% of Wilms tumors involve vascular extension, requiring a complex surgical approach that influences management but not prognosis.
- A study of 69 pediatric patients with Wilms tumors revealed significant findings, including a 37.5% rate of right atrial extension and complications like pulmonary embolism.
- Despite challenges, the use of neoadjuvant chemotherapy led to a high overall survival rate of 89%, though postoperative renal insufficiency was identified as a risk factor for reduced survival.