Publications by authors named "C C Whitelaw"
Background: Cardiovascular disease causes vascular dementia and contributes to most clinical dementia. This is embodied in the concept of vascular contributions to cognitive impairment and dementia (VCID). The potent endogenous peptide endothelin-1 (ET1) causes small artery vasoconstriction and fibrosis.
View Article and Find Full Text PDFThe biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework.
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- Highly expressed gene loci, like those for casein, are ideal targets for inserting transgenes due to their abundant protein production in mammals, particularly in milk.
- The α-casein gene was successfully used as a site for transgene insertion in mice, allowing for the expression of an antibody light chain (A1L) that is secreted into milk.
- While transgene expression in these mice was stable, it was much lower than the native α-casein production, leading to reduced total milk protein and poor growth in pups fed by homozygous transgenic mothers.
Markerless motion capture methods are continuously in development to target limitations encountered in marker-, sensor-, or depth-based systems. Previous evaluation of the KinaTrax markerless system was limited by differences in model definitions, gait event methods, and a homogenous subject sample. The purpose of this work was to evaluate the accuracy of spatiotemporal parameters in the markerless system with an updated markerless model, coordinate- and velocity-based gait events, and subjects representing young adult, older adult, and Parkinson's disease groups.
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