Publications by authors named "C C Trowbridge"
Article Synopsis
- The study investigates the effectiveness of individualized heparin dosing during cardiopulmonary bypass (CPB) based on measured blood heparin concentration, as opposed to the traditional method that uses total body weight.
- A meta-analysis of 26 studies with 3,810 patients showed that individualized dosing significantly reduced postoperative blood loss, improved platelet counts, and resulted in a better protamine-to-heparin ratio compared to weight-based dosing.
- The findings suggest that real-time monitoring and individualized adjustments of heparin may lead to better outcomes after CPB, although the overall impact on clinical guidelines still needs further exploration.
Epinephrine iontophoresis attenuates changes in skin blood flow and abolishes cutaneous contamination of near-infrared diffuse correlation spectroscopy estimations of muscle perfusion.
Miles F Bartlett Alberto Palmero-Canton Andrew P Oneglia Julissa Mireles R Matthew Brothers Cynthia A Trowbridge
Am J Physiol Regul Integr Comp Physiol
March 2023
Near-infrared diffuse correlation spectroscopy (NIR-DCS) is an optical imaging technique for measuring relative changes in skeletal muscle microvascular perfusion (i.e., fold change above baseline) during reactive hyperemia testing and exercise and is reported as a blood flow index (BFI).
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- A study explored how aging affects brain networks using functional near-infrared spectroscopy (fNIRS), which measures brain activity.
- Researchers recorded resting-state signals from 48 participants, including both young and older adults, and analyzed the data using graph theory.
- Findings revealed that older adults experienced a decline in brain network efficiency and hub shifts, indicating potential impairments in decision-making and memory functions compared to younger adults.
Problem: Chronic conditions are major health problems for Australian Aboriginal people. Self-management programs can improve health outcomes. However, few health workers are skilled in self-management support and existing programs are not always appropriate in Australian Aboriginal contexts.
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