Publications by authors named "C C Shayo"
Prolactinomas, the most common pituitary-secreting adenomas, can be effectively treated with dopamine D2 receptor (D2R) agonists. However, a subset of them (∼20%) are resistant to dopamine-based therapies and require extirpation. The molecular mechanisms underlying their escape from dopaminergic regulation are not fully elucidated and may include alterations in D2R signaling.
View Article and Find Full Text PDFArticle Synopsis
- PDAC is a highly aggressive cancer that is hard to treat, often not responding well to standard chemotherapy like Gemcitabine.
- Researchers found that the transporter protein MRP4 plays a key role in the cancer's growth by excluding cAMP, and they are exploring it as a target for new therapies.
- In their study, they identified flurbiprofen as the most effective drug among several NSAIDs for inhibiting MRP4, enhancing the effectiveness of Gemcitabine against PDAC cells.
The xenobiotic transporter /MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity. Here, we show that promotes epithelial-mesenchymal transition (EMT) in PDAC, a hallmark process involving the acquisition of mesenchymal traits by epithelial cells, enhanced cell motility, and chemoresistance. Modulation of levels in PANC-1 and BxPC-3 cell lines resulted in the dysregulation of genes present in the EMT signature.
View Article and Find Full Text PDFArticle Synopsis
- - The Dar es Salaam Global Neurosurgery Course was held in March 2023 to address the lack of local training for neurosurgeons in Tanzania, providing an alternative to overseas education which can be costly and burdensome.
- - The course trained 121 participants with a mix of local and international faculty using various teaching methods such as lectures, hands-on practice, and surgical simulations, despite some challenges like internet connectivity.
- - Feedback from participants indicated a positive impact on their neurosurgical knowledge, highlighting the effectiveness of international collaboration in enhancing local training and suggesting expansion into related topics for future courses.
Background: In nations where tree harvesting constitutes a significant aspect of the economy, such as Tanzania, falls from trees represent a prevalent cause of traumatic injuries. This study investigates the characteristics of traumatic spinal injuries (TSIs) resulting from falls from coconut trees. (CTFs).
View Article and Find Full Text PDF