Effects of diesel exhaust inhalation on cognitive performance in human volunteers: A randomized controlled crossover study.

Background: Mounting evidence links exposure to traffic-related air pollution (TRAP) to impairment in cognitive functioning.

Objectives: To determine if short-term, controlled exposure to diesel exhaust (DE) adversely affects one or more cognitive function domains.

Methods: We carried out a double-blinded crossover design with 28 healthy, adult volunteers.

Management of phthalates in Canada and beyond: can we do better to protect human health?

Ortho-phthalates (herein referred to as phthalates) are synthetic chemicals used in thousands of different everyday products and materials. Nearly ubiquitous environmental exposure is reflected by phthalate metabolites in the urine of almost all Canadians. However, phthalate exposure tends to be higher amongst people of low socioeconomic status and ethnic minorities.

Novel ryanodine receptor 1 (RYR1) missense gene variants in two pet dogs with fatal malignant hyperthermia identified by next-generation sequencing.

Objective: Evaluate a precision medicine approach to confirm a tentative diagnosis of fatal malignant hyperthermia (MH) in isoflurane-anesthetized pet dogs by identifying novel risk variants in known MH susceptibility genes.

Study Design: Retrospective case series.

Animals: A male Pit Bull mix aged 7 years (case #1), a male Golden Retriever aged 12 months (case #2) and the dam and sire of case #2.

Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer classification scheme.

The Cramer classification scheme has emerged as one of the most extensively-adopted predictive toxicology tools, owing in part to its employment for chemical categorisation within threshold of toxicological concern evaluation. The characteristics of several of its rules have contributed to inconsistencies with respect to degree of hazard attributed to common (particularly food-relevant) substances. This investigation examines these discrepancies, and their origins, raising awareness of such issues amongst users seeking to apply and/or adapt the rule-set.

Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.

One of the most pressing issues in global health is air pollution. Emissions from traffic-related air pollution and biomass burning are two of the most common sources of air pollution. Diesel exhaust (DE) and wood smoke (WS) have been used as models of these pollutant sources in controlled human exposure (CHE) experiments.