Publications by authors named "C C Orlowski"
Phosphorylated histone H2AX (γH2AX) represents a sensitive molecular marker of DNA double-strand breaks (DSBs) and is implicated in stem cell biology. We established a model of mouse embryonic stem cell (mESC) differentiation and examined the dynamics of γH2AX foci during the process. Our results revealed high numbers of γH2AX foci in undifferentiated mESCs, decreasing as the cells differentiated towards the endothelial cell lineage.
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- Multidisciplinary meetings (MDMs) significantly influence decision-making in breast cancer patient care, with a study showing that 66% of cases had changes in their management plans after MDM discussions.
- The research involved comparing pre-MDM management predictions with MDM recommendations across various treatment domains and assessing the implementation rates of these recommendations three months later.
- Results indicated that 83.7% of MDM recommendations were successfully put into practice, underscoring the importance of MDMs while also suggesting a need to address barriers to implementing these recommendations.
Eventual Convergence of the Reputation-Based Algorithm in IoT Sensor Networks.
Sensors (Basel)
September 2021
Uncertainty in dense heterogeneous IoT sensor networks can be decreased by applying reputation-inspired algorithms, such as the EWMA (Exponentially Weighted Moving Average) algorithm, which is widely used in social networks. Despite its popularity, the eventual convergence of this algorithm for the purpose of IoT networks has not been widely studied, and results of simulations are often taken in lieu of the more rigorous proof. Therefore the question remains, whether under stable conditions, in realistic situations found in IoT networks, this algorithm indeed converges.
View Article and Find Full Text PDFThe growing popularity of inexpensive IoT (Internet of Things) sensor networks makes their uncertainty an important aspect of their adoption. The uncertainty determines their fitness for purpose, their perceived quality and the usefulness of information they provide. Nevertheless, neither the theory nor the industrial practice of uncertainty offer a coherent answer on how to address uncertainty of networks of this type and their components.
View Article and Find Full Text PDFObjectives: To report an unusual case of simultaneous presentation of Addison's and Graves' disease in an adolescent female previously diagnosed with type 1 diabetes (T1D) and Hashimoto's.
Case Presentation: A 15-year-old female with T1D and hypothyroidism presented to the emergency department with altered mental state, fever, and left arm weakness for one day. Clinical work-up revealed coexistent new-onset adrenal insufficiency and hyperthyroidism.