Publications by authors named "C C Noronha"

Article Synopsis
  • The outpatient continuity clinic is vital for internal medicine residency training, and the Primary Care Exception Rule (PCER) allows indirect supervision of residents during less complex patient visits.
  • The existing literature on the effects of the PCER is limited, yet it raises questions about its impact on patients, residents, attending physicians, and health systems.
  • Recommendations include avoiding PCER for critical diagnosis situations, advocating for competency-based supervision, and expanding the PCER to cover moderate-complexity visits, along with a call for further research in this area.
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Medical education continues to evolve with technologic advances, cultural changes, and progress in the application of learning theories. One example is Cutrer's concept of the Master Adaptive Learner (MAL), where the trainee self-directs learning and innovates to maintain a level of expertise in a domain. We suggest that this concept can be applied alongside ideas of adaptive and teacher expertise to represent the medical educator of the future-the Master Adaptive Clinician Educator (MACE).

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Unlabelled: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the presence of antiphospholipid antibodies and venous and arterial thrombotic events, including obstetric complications. We describe the case of a 56-year-old female diagnosed with APS with triple antibody positivity and multiple disease-associated manifestations, namely recurrent purpuric lesions, adrenal insufficiency due to infarction, acalculous cholecystitis, and three spontaneous abortions. Her follow-up was marked by severe thrombotic and haemorrhagic events, notably splanchnic vein thrombosis and haemorrhagic shock after a renal biopsy, as well as the diagnosis of systemic lupus erythematosus 8 years after the APS diagnosis.

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Article Synopsis
  • Cadherins are important proteins involved in cell adhesion and play a crucial role in cancer progression, particularly in glioblastoma, which is an aggressive brain tumor.
  • A study analyzed N-, E-, and P-cadherin expression in a large group of GBM cases and found that N-cadherin was most common, while P-cadherin was notably upregulated in recurrent tumors.
  • Co-expression of different cadherins revealed distinct GBM subgroups, with E- and N-cadherin linked to better survival outcomes, while those expressing P-cadherin were associated with more aggressive tumor characteristics and poorer prognosis.
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The relation between positive youth development and stress, anxiety and depression was studied considering the mediator role of psychological symptoms and life satisfaction. A total of 3109 students included in the "Psychological Health and Well-being" study of the School Observatory participated, including 1618 females and 1491 males aged between 11 and 18 years old ( = 14.45; = 1.

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