Publications by authors named "C C Mourani"
Article Synopsis
- Nedosiran is an experimental RNA interference treatment aimed at reducing the production of oxalate by inhibiting an enzyme involved in its synthesis, targeting primary hyperoxaluria (PH) patients.
- In a six-month study, participants receiving nedosiran experienced a significant reduction in 24-hour urinary oxalate levels compared to those given a placebo, with half of the nedosiran group achieving normal or near-normal excretion levels.
- The treatment was well tolerated with low rates of mild injection-site reactions, showing promising results in lowering oxalate levels in patients with PH1, while the effects in patients with PH2 were less consistent.
Rationale & Objective: Lumasiran reduces urinary and plasma oxalate (POx) in patients with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function. ILLUMINATE-C evaluates the efficacy, safety, pharmacokinetics, and pharmacodynamics of lumasiran in patients with PH1 and advanced kidney disease.
Study Design: Phase 3, open-label, single-arm trial.
Management of acute liver failure (ALF) and acute on chronic liver failure (ACLF) in the pediatric population can be challenging. Kidney manifestations of liver failure, such as hepatorenal syndrome (HRS) and acute kidney injury (AKI), are increasingly prevalent and may portend a poor prognosis. The overall incidence of AKI in children with ALF has not been well-established, partially due to the difficulty of precisely estimating kidney function in these patients.
View Article and Find Full Text PDFIntroduction: Recently, prolonged intermittent renal replacement therapies (PIRRT) have emerged as cost-effective alternatives to conventional CRRT and their use in the pediatric population has started to become more prominent. However, there is a lack of consensus guidelines on the use of PIRRT in pediatric patients in an intensive care setting.
Methods: A literature search was performed on PubMed/Medline, Embase, and Google Scholar in conjunction with medical librarians from both India and the Cleveland Clinic hospital system to find relevant articles.