Publications by authors named "C C McDougall"
Article Synopsis
- Fecal microbiota transplantation (FMT) was evaluated for its ability to induce remission in Crohn's disease (CD) in a double-blind study, marking the first investigation of its kind.
- The study involved 21 patients receiving FMT and 13 receiving a placebo, and was terminated early due to futility, showing no significant difference in remission rates between groups at week 8.
- While FMT did not improve clinical outcomes, both groups reported improvements in health-related quality of life; future research may explore alternative strategies to boost treatment efficacy.
Article Synopsis
- KMT2C and KMT2D are important enzymes that modify genes, with KMT2C haploinsufficiency recently linked to Kleefstra syndrome 2, a neurodevelopmental disorder (NDD) with unknown clinical details.
- A study involving 98 individuals found that most pathogenic variants in KMT2C span nearly all its exons, making variant interpretation difficult; the study also established a KMT2C DNA methylation signature for better classification of the disorder.
- Key features of KMT2C-related NDD include developmental delays, intellectual disabilities, and distinct facial characteristics, setting it apart from similar conditions like Kleefstra and Kabuki syndromes, indicating the need for its renaming and
Background: The ecology and biology of oysters (Ostreidae) across the tropics is poorly understood. Morphological plasticity and shared characteristics among oysters have resulted in the misidentification of species, creating challenges for understanding basic species-specific biological information that is required for restoration and aquaculture. Genetic barcoding has proven essential for accurate species identification and understanding species geographic ranges.
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