Dynamic Lipidomics and Transcriptome Profiling Reveals the Transcriptional Regulatory Mechanism Governing TAGs Formation in Seeds of Safflower.

Safflower ( L.) is a valuable oil crop due to its bioactive ingredients and high linoleic acid content, which contribute to its antioxidant properties and potential for preventing atherosclerosis. Current research on safflower focuses on understanding the biosynthesis of seed oil through omics strategies, yet there is a lack of comprehensive knowledge of the dynamic changes in lipids and the regulatory mechanisms during seed development.

Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets.

Purpose: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease. PANoptosis, a unique inflammatory programmed cell death, it manifests as the simultaneous activation of signaling markers for pyroptosis, apoptosis, and necroptosis. However, research on the role of PANoptosis in the development of IPF is currently limited.

Decoding TDP-43: the molecular chameleon of neurodegenerative diseases.

TAR DNA-binding protein 43 (TDP-43) has emerged as a critical player in neurodegenerative disorders, with its dysfunction implicated in a wide spectrum of diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer's disease (AD). This comprehensive review explores the multifaceted roles of TDP-43 in both physiological and pathological contexts. We delve into TDP-43's crucial functions in RNA metabolism, including splicing regulation, mRNA stability, and miRNA biogenesis.

A case of transient elevation of creatinine caused by severe hyperuricemia.

Background: To explore the underlying causes of significant fluctuations in creatinine levels within three days due to transient and severe uric acid elevation, and to provide evidence for the interpretation of abnormal test results and clinical diagnosis and management.

Methods: The issues were resolved by retesting the samples, comparing results across different detection platforms, and analyzing the reaction curve. We comprehensively reviewed patients' general conditions, imaging examinations, and treatments.

Association of frailty and chronic limb-threatening ischemia in patients on maintenance hemodialysis: a prospective cohort study.

Chronic limb-threatening ischemia (CLTI) is a prevalent yet unpredictable complication among patients undergoing hemodialysis, and frailty is linked to adverse outcomes in this population. This study examined the influence of clinical factors on vascular events in patients undergoing hemodialysis. This multicenter prospective cohort study included patients undergoing maintenance hemodialysis since January 2008.