Publications by authors named "C C Ibegbu"
Article Synopsis
- Ovarian hormones influence the immune system in the female genital tract (FGT), and this study explores how the menstrual cycle affects HIV target cell levels and memory CD4 T cells.
- Researchers collected endocervical cells from 105 healthy women and analyzed different CD4 T cell subsets, focusing on their distribution and function during the follicular and luteal phases of the menstrual cycle.
- Results showed that certain CD4 T cell types were more prevalent in the follicular phase, which may increase susceptibility to HIV, highlighting the dynamic changes in immune response linked to hormonal fluctuations throughout the menstrual cycle.
Article Synopsis
- AJHP is releasing accepted manuscripts online quickly after peer review and editing, but these are not the final versions and will later be replaced with properly formatted articles.
- Elevated bromide levels can lead to various health issues, including neurological problems, and might affect chloride tests, giving inaccurate results.
- A case study of a 37-year-old man with myasthenia gravis showed he developed high bromide levels and neurological symptoms after receiving pyridostigmine bromide, highlighting the need for awareness of bromide toxicity from this medication.
Cytokines are key mediators of immune regulation, orchestrate communication between immune cells, and play a pivotal role in shaping the immune landscape during chronic infection and cancer. The therapeutic potential of IL-15/IL-15Rα and IL-12 has been explored individually in various immunotherapeutic strategies, though not as a combination. Therefore, we investigated whether the combination of IL-15/IL-15Rα and IL-12 treatment would enhance the potency and quality of either NK cells, SIV-specific CD8 T cells, or both, compared with single cytokine treatment.
View Article and Find Full Text PDFPlasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for Plasmodium vivax and Plasmodium ovale. Each of these species produces hypnozoites in the liver, which can cause relapsing infections in the blood. Here we present methods and data generated from iterative longitudinal systems biology infection experiments designed and performed by the Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into the biology, pathogenesis, and immune responses of P.
View Article and Find Full Text PDFThe persistence of virally infected cells as reservoirs despite effective antiretroviral therapy is a major barrier to an HIV/SIV cure. These reservoirs are predominately contained within cells present in the B cell follicles (BCFs) of secondary lymphoid tissues, a site that is characteristically difficult for most cytolytic antiviral effector cells to penetrate. Here, we identified a population of NK cells in macaque lymph nodes that expressed BCF-homing receptor CXCR5 and accumulated within BCFs during chronic SHIV infection.
View Article and Find Full Text PDF