Publications by authors named "C C Hedrick"
Glioblastoma (GBM) is the most frequent malignant brain tumor. We recently discovered that oncolytic herpes simplex virus engineered to disable tumor-intrinsic protein kinase R (PKR) signaling (oHSV-shPKR) could increase oHSV oncolysis and anti-tumor immune response. However, here we show that disabling tumor-intrinsic PKR signaling can also induce the activation of the indoleamine 2,3-dioxygenase (IDO) signaling pathway.
View Article and Find Full Text PDFAims: Olfactory receptor 2 (Olfr2) has been identified in a minimum of 30% of vascular macrophages, and its depletion was shown to reduce atherosclerosis progression. Mononuclear phagocytes, including monocytes and macrophages within the vessel wall, are major players in atherosclerosis. Single-cell RNA sequencing studies revealed that atherosclerotic artery walls encompass several monocytes and vascular macrophages, defining at least nine distinct subsets potentially serving diverse functions in disease progression.
View Article and Find Full Text PDFArticle Synopsis
- IgMs produced by a specific subtype of B cells protect against inflammation and diet-induced atherosclerosis by inactivating harmful lipid oxidation products.
- This study identifies human marginal zone B (MZB) cells as the main source of these protective IgMs through advanced techniques like single-cell mass cytometry and testing in humanized mice.
- Treatment that reduces MZB cells leads to increased vascular inflammation, showing their protective role, while findings also indicate that higher MZB cell presence correlates with less severity in coronary artery disease in patients.