A pilot study of a targeted cognitive intervention for cancer survivors.

Purpose: The primary aims of this four week pilot randomized clinical trial (RCT) involving a targeted cognitive intervention (TCI, n = 25) compared to an expectancy matched active control intervention (EMACI, n = 24), in a sample of cancer survivors were to: determine recruitment and retention rates; evaluate preliminary efficacy to improve three objective measures of cognitive function (i.e., attention, working memory, multi-tasking); evaluate adherence rates for and satisfaction with the interventions, and evaluate for treatment-related adverse events (e.

Benchmarking Spatial Co-Localization Methods for Single-Cell Multiplex Imaging Data with Applications to High-Grade Serous Ovarian and Triple Negative Breast Cancer.

Single-cell multiplex imaging (scMI) measures cell locations and phenotypes within a tissue and can be used to understand the tumor microenvironment. In scMI studies, it is often of interest to quantify spatial co-localization of immune cells and its association with clinical outcomes; however, it remains unknown which of the many available spatial indices have adequate power to detect spatial within-sample co-localization and its association with patient outcomes, such as survival. In this study, the performance of six frequentist metrics of spatial co-localization used in scMI studies were evaluated.

Perturbations in the neuroactive ligand-receptor interaction and renin angiotensin system pathways are associated with cancer-related cognitive impairment.

Purpose: This study reports on the results from our data-driven approach that identified perturbations in neuroactive ligand-receptor interaction and renin-angiotensin system (RAS) pathways in oncology patients with and without self-reported cancer-related cognitive impairment (CRCI).

Methods: In a sample of oncology patients receiving chemotherapy (n = 1343), the Attentional Function Index (AFI) was used to assess CRCI. Patients were grouped into low (AFI score of < 5) versus high (AFI score of > 7.

Neonatal Surgery for Congenital Lung Malformations: Indications, Outcomes and Association With Malignancy.

Aim Of The Study: Congenital lung malformations (CLM) are a heterogeneous group of anomalies diagnosed with increasing frequency antenatally. Postnatal management is dictated by the clinical status in the early neonatal period. We report our centre's experience in managing symptomatic neonates with CLM.

Knowledge, Attitude and Practices of Areca Nut (kwai) Use among Employees of a Tertiary Health Care Institution in North-East India.

Objective: This study strives to look for the knowledge, attitudes, and practices of areca nut use among health care workers in a tertiary hospital in North-East India.

Methods: A prospective, cross-sectional, questionnaire-based study was conducted among all health care and allied workers at a public sector teaching hospital in Meghalaya, Northeast India. A questionnaire, which was validated for content, was administered to the target population.