Publications by authors named "C C Finn"
Specialized memory CD4 T cells that reside long-term within tissues are critical components of immunity at portals of pathogen entry. In the lung, such tissue-resident memory (TRM) cells are activated rapidly after infection and promote local inflammation to control pathogen levels before circulating T cells can respond. However, optimal clearance of Influenza A virus can require TRM and responses by other virus-specific T cells that reach the lung only several days after their activation in secondary lymphoid organs.
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- Normohormonal primary hyperparathyroidism involves high calcium levels with normal parathyroid hormone, and previous studies indicated that a significant decrease in parathyroid hormone during surgery predicts successful treatment and helps prevent low calcium levels post-surgery.
- In a study analyzing over 1,000 patients, findings showed similar cure rates between normohormonal (94%) and classic primary hyperparathyroidism (92%), although the average decrease in hormone levels during surgery was lower in normohormonal cases.
- When applying the earlier established thresholds for hormone reduction, the study confirmed high predictive values for successful treatment and low risk of hypocalcemia for both types of hyperparathyroidism.
Article Synopsis
- The study investigates synaptic density in autistic adults using positron emission tomography (PET) and synaptic vesicle glycoprotein 2A (SV2A) as a marker.
- Results show that autistic individuals exhibit a 17% lower synaptic density across the whole cortex compared to non-autistic peers, with significant deficits in various brain regions, especially the prefrontal cortex.
- The findings suggest that lower synaptic density is associated with increased autistic features, pointing to a potential molecular basis for autism that requires further exploration.
Importance: At least 10 million people in the United States have an intellectual and/or developmental disability (IDD). People with IDD experience considerably higher rates of poor overall health, chronic conditions including diabetes, mental health challenges, maternal mortality, and preventable deaths. This Special Communication proposes national goals based on a community-led consensus model that advances priority health outcomes for people with IDD and their caregivers/partners and identifies critical policy opportunities and challenges in achieving these goals.
View Article and Find Full Text PDFObjective: To establish whether Accreditation Council for Graduate Medical Education Milestones predict future performance of general surgery trainees.
Summary Background Data: Milestones provide bi-annual assessments of trainee progress across six competencies. It is unknown whether the Milestones predict surgeon performance after the transition to independent practice.