Publications by authors named "C C Dim"
Background: There are reports of a high prevalence of maternal peripheral and placental malarial parasitaemia (MP) in southeastern Nigeria following the two-dose regimen of sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment (IPT) of malaria in pregnancy.
Objective: To compare the effectiveness of monthly versus two-dose regimens of SP for IPT of malaria in pregnancy in Enugu, south-eastern Nigeria.
Methods: A randomized controlled trial involving antenatal clinic attendees at the University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria.
Setting: This study is a retrospective review of a large-scale systematic TB screening project conducted in six states of Nigeria.
Objective: To determine the magnitude and characteristics of subclinical TB and the relative contributions of bacteriological versus clinical diagnosis in its identification in Nigeria.
Design: Data were retrospectively analysed from six states of Nigeria, where parallel screening with any TB symptoms and chest X-ray (CXR) with artificial intelligence (AI) was used for active case finding.
Succinimide and its derivatives are cyclic five-membered rings that appear in a variety of natural products and are widely used in organic synthesis. From a structural standpoint, succinimide contains an NH group in the ring which interacts with two adjacent carbonyl groups, pushing the ring structure toward planarity at the expense of increasing ring strain and eclipsing interactions among the out-of-plane hydrogen atoms in the two CH groups. Previous quantum chemical calculations at different levels of theory have predicted both a nonplanar structure and a planar structure, the latter of which is the most consistent with gas-phase electron diffraction measurements.
View Article and Find Full Text PDFOwing to their continuous evolution, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) display disparate pathogenicity in mouse models. Omicron and its sublineages have been dominant worldwide. Compared to pre-Omicron VOCs, early Omicron subvariants reportedly cause attenuated disease in human ACE-2-expressing mice (K18-hACE-2).
View Article and Find Full Text PDFArticle Synopsis
- Hypertension (HTN) is increasingly becoming a critical health issue in the U.S., with a rise in related cardiovascular deaths, particularly when it becomes refractory, or treatment-resistant.
- Key risk factors for refractory HTN are linked to demographics (African ancestry, young age, and female gender), health conditions (diabetes, obesity, sleep apnea, kidney disease), and lifestyle choices (smoking).
- The text also emphasizes three key areas to focus on: understanding the risk factors for refractory hypertension, the potential role of surgical interventions in its management, and the existing referral systems to support patients with refractory HTN.