A novel combinatorial approach integrating experimental and computational analysis of antioxidant activity: Evaluating catechin and L-ascorbic acid in serum.

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally, with oxidative stress playing a pivotal role in its progression. Free radicals produced via oxidative stress contribute to lipid peroxidation, leading to subsequent inflammatory responses, which then result in atherosclerosis. Antioxidants inhibit these harmful effects through their reducing ability, thereby preventing oxidative damage.

Spatio-Temporal Analysis of Drought Variability Using CWSI in the Koshi River Basin (KRB).

Drought is one of the most frequent meteorological disasters, and has exerted significant impacts on the livelihoods and economy of the Koshi River Basin (KRB). In this study, we assessed drought patterns using the Crop Water Shortage Index (CWSI) based on the MOD16 product for the period between 2000 and 2014. The results revealed that the CWSI based on the MOD16 product can be act as an indicator to monitor the characteristics of the drought.

Absorption of glucose polymers from canine jejunum deprived of pancreatic amylase.

We evaluated the absorption of glucose polymers in canine jejunal Thiry-Vella fistulas proven to be free of pancreatic amylase. Medium-length oligomers with degrees of polymerization of 6 through 10 glucose units (DP 6-10) and long-chain material (DPavg23) were isolated from a cornstarch hydrolysate. We perfused 90, 180, and 360 mg/dl solutions of glucose, DP 6-10, and DPavg23 at 0.

An ultrastructural study of the intimal injury induced by an indwelling umbilical artery catheter.

In an experimental study, catheterization of the abdominal aorta with small umbilical artery catheters consistently produced significant intimal injury. The duration of catheterization varied from 1 hr to 7 days, and recovery periods following catheter removal varied from 1-150 days. Endothelial disruption was observed in all animals sacrificed within 24 hr of catheter removal.

Collagen formation by transformed smooth muscle cells after arterial injury.

Twenty-five normocholesterolemic rabbits were sacrificed at intervals up to 60 days after the thoracic aortas were de-endothelialized. Ultrastructural studies of both the re-endothelialized and nonendothelialized intima were done. The smooth muscle cells in the re-endothelialized intima showed segmental structural changes typically associated with transformation to a secretory cell type; abundant accumulations of collagen were in juxtaposition with these cells.