Publications by authors named "C C Avcı"
Precision oncology: Using cancer genomics for targeted therapy advancements.
Biochim Biophys Acta Rev Cancer
December 2024
Cancer genomics plays a crucial role in oncology by enhancing our understanding of how genes drive cancer and facilitating the development of improved treatments. This field meticulously examines various cancers' genetic makeup through various methodologies, leading to groundbreaking discoveries. Innovative tools such as rapid gene sequencing, single-cell studies, spatial gene mapping, epigenetic analysis, liquid biopsies, and computational modeling have significantly progressed the field.
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- - This review discusses how machine learning (ML) is transforming oncological pharmacogenomics by analyzing data to customize chemotherapy treatments, leading to more effective and personalized therapies with fewer side effects.
- - It highlights the role of ML in identifying genetic patterns that influence drug responses and integrating this information with electronic health records to enhance treatment recommendations, moving beyond traditional population-based approaches.
- - The review also identifies challenges in the field, such as model interpretability, data quality, ethical concerns about privacy, and health disparities, while stressing the need for rigorous clinical trials and interdisciplinary collaboration to responsibly implement ML in cancer treatment.
How Does Illness Perception Affect the Quality of Life and Sun Protection Behaviors of Rosacea Patients?
Photodermatol Photoimmunol Photomed
September 2024
Background: Previous studies have noted the link between rosacea severity and quality of life, but there is limited understanding of how disease perception impacts these aspects. Additionally, sun exposure is identified as a common trigger for rosacea flare-ups, emphasizing the importance of sun protection practices in managing the condition. This cross-sectional study aims to fill the gap in the literature by investigating the relationship between clinical severity, disease perception, quality of life, and sun protection behaviors in rosacea patients.
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- Recent studies highlight the importance of autophagy in the function and regenerative capabilities of mesenchymal stem cells (MSCs), particularly its role in the formation of tunneling nanotubes (TNTs) and mitochondrial donation.
- The experiment employed Metformin and 3-methyladenine to assess the effects of autophagy modulation on TNT length and mitochondrial function in MSCs, revealing that autophagy stimulation increased TNT characteristics while inhibition dampened them.
- The findings suggest that altering autophagy impacts various signaling pathways, indicating its potential influence on MSC behavior and cellular interactions.