Publications by authors named "C Butel"
Background: Several variants of SARS-CoV-2 have a demonstrated impact on public health, including high and increased transmissibility, severity of infection, and immune escape. Therefore, this study aimed to determine the SARS-CoV-2 lineages and better characterize the dynamics of the pandemic during the different waves in Guinea.
Methods: Whole genome sequencing of 363 samples with PCR cycle threshold (Ct) values under thirty was undertaken between May 2020 and May 2023.
From the perspective of developing relevant interventions for treating HIV and controlling its spread, it is particularly important to comprehensively understand the underlying diversity of the virus, especially in countries where the virus has been present and evolving since the cross-species transmission event that triggered the global pandemic. Here, we generate and phylogenetically analyse sequences derived from the (2010 bp; = 115), partial (345 bp; = 36), and (719 bp; = 321) genes of HIV-1 group M (HIV-1M) isolates sampled between 2000 and 2022 from two cosmopolitan cities and 40 remote villages of Cameroon. While 52.
View Article and Find Full Text PDFBackground And Objectives: Data on HIV drug resistance in Madagascar are rare and outdated. In this study, we assessed the prevalence of HIV drug resistance mutations to antiretrovirals (ARVs) and genetic diversity of circulating strains in treatment-naive people living with HIV (PLHIV) in Madagascar.
Materials And Methods: We amplified the protease (PR), fragments of the Reverse Transcriptase (RT) and Integrase (IN) genes according to the French ANRS protocol.
Genomic surveillance of dengue virus in Benin.
Infect Genet Evol
November 2024
Article Synopsis
- Dengue is a viral infection spread by mosquitoes, and this study in Benin aimed to investigate the presence of different serotypes beyond the previously recorded DENV serotype 2.
- The research involved analyzing plasma samples from 464 patients for dengue infection using advanced PCR techniques, which led to the identification of DENV-1 and DENV-3 serotypes in three patients.
- This finding highlights the importance of enhancing arbovirus surveillance in Benin, indicating the need for better monitoring of emerging infections.
Article Synopsis
- The study focuses on the high genetic diversity of HIV-1M in the Congo Basin, where the epidemic began over a century ago, analyzing 148 samples from the Democratic Republic of the Congo collected between 1997 and 2013.
- Researchers used PCR and sequencing methods to identify 22 different subtypes and 15% unique recombinant forms (URFs), alongside rare subtypes such as H, J, and K.
- Two specific amino acid motifs related to HIV-1 replication and fitness were found in the samples, but there was no clear correlation between these motifs and the different subtypes, indicating a need for further research on their effects.