The impact of antifibrotic use on long-term clinical outcomes in the pulmonary fibrosis foundation registry.

Background: Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with a high mortality rate. The antifibrotic medications pirfenidone and nintedanib have been in use since 2014 for this disorder and are associated with improved rate of lung function decline. Less is known about their long-term outcomes outside of the clinical trial context.

Experimental Test of Sinai's Model in DNA Unzipping.

The experimental measurement of correlation functions and critical exponents in disordered systems is key to testing renormalization group (RG) predictions. We mechanically unzip single DNA hairpins with optical tweezers, an experimental realization of the diffusive motion of a particle in a one-dimensional random force field, known as the Sinai model. We measure the unzipping forces F_{w} as a function of the trap position w in equilibrium and calculate the force-force correlator Δ_{m}(w), its amplitude, and correlation length, finding agreement with theoretical predictions.

Real-World Clinical Outcomes Based on Body Mass Index and Annualized Weight Change in Patients with Idiopathic Pulmonary Fibrosis.

Introduction: Identification of clinical characteristics associated with prognosis for idiopathic pulmonary fibrosis (IPF) may help to guide management decisions. This analysis utilized data from the Pulmonary Fibrosis Foundation Patient Registry to examine the relationships between clinical outcomes and both body mass index (BMI) at study enrollment (hereafter referred to as baseline BMI) and annualized percent change in body weight in patients with IPF in a real-world setting.

Methods: The following outcomes over 24 months were stratified by baseline BMI and annualized percent change in body weight: all-cause mortality; annualized change in percent predicted forced vital capacity (%FVC), percent predicted diffusing capacity for carbon monoxide, and 6-min walk distance; all-cause and respiratory-related hospitalizations; and acute exacerbations.

Force Correlations in Disordered Magnets.

We present a proof of principle for the validity of the functional renormalization group, by measuring the force correlations in Barkhausen-noise experiments. Our samples are soft ferromagnets in two distinct universality classes, differing in the range of spin interactions, and the effects of eddy currents. We show that the force correlations have a universal form predicted by the functional renormalization group, distinct for short-range and long-range elasticity, and mostly independent of eddy currents.