Publications by authors named "C Bures"
Parathyroidectomy (PTX) is a mainstay of treating secondary hyperparathyroidism (SHPT) in patients with kidney failure in order to reduce the incidence of cardiovascular events (CVE), increase overall survival and improve quality of life. Perioperative hyperkalemia may lead to devastating cardiac complications. Distinct preoperative thresholds for serum potassium levels (SPL) were defined, but neither their usefulness nor consecutive risks are understood.
View Article and Find Full Text PDFβ-Catenin activation and illicit receptor expression in adrenocortical cells.
Endocr Relat Cancer
February 2022
Article Synopsis
- Adrenal cortisol-producing tumors can express inappropriate receptors, including LH, GIP, and serotonin receptors, due to altered signaling pathways like Wnt/β-catenin.
- The study tested β-catenin activation using various models and found abnormal expression of GIP, 5-HT7, and LH receptors in tumor tissues, but only LH receptors were upregulated in other cell models.
- Results suggest that while β-catenin activation leads to increased functional LH receptor expression in adrenal cells, it does not promote the abnormal expression of GIP and serotonin receptors.
Background: Laparoscopic conversion of Nissen Fundoplication to Roux-en-Y gastric bypass (RYGB) is a complex procedure due to increased operative time, morbidity, and length of hospital stay (LOS). In this study, a new simplified technique avoiding the total dismantling of the previous Nissen repair to construct the gastric pouch, the so-called hug technique is presented for the conversion of Nissen fundoplication to RYGB.
Methods: The present study is a prospective single-center clinical series reporting on the feasibility and safety of the "hug" technique for the creation of laparoscopic RYGB.
Background: Timing of parathyroidectomy (PTX) remains controversial in candidates for kidney transplant with concomitant renal hyperparathyroidism (HPT). The aim of this retrospective study was to identify the influence of early vs late posttransplant PTX compared to pretransplant PTX on renal graft function and morbidity.
Methods: This single-center cohort study includes 57 patients with renal HPT and kidney transplantation treated between 2007 and 2017.
Introduction: Gender has been proven to influence the pathophysiology and treatment of numerous diseases, including kidney diseases and hormonal dysfunction like hyperparathyroidism. Thus, higher parathormone levels have been demonstrated in women with end-stage kidney disease, when compared to men.
Objectives: We questioned whether female gender is associated with an increased risk for parathyroid nodular hyperplasia and necessary parathyroidectomy in dialysis patients and assessed demographics as well as outcome data for women and men undergoing parathyroidectomy for renal hyperparathyroidism.